What are you up to? 最近忙什么啊?
A: I haven't seen you around lately. What are you up to?
A: 最近都没看到你。 忙什么呢?
B: I'm working two jobs right now. It's killing me.
B: 我现在做二份工作。把我累死了!
"It's killing me." 是表示某事很折腾人的意思。
如"Her singing is killing me." 她的歌声(很恐怖)简直要我的命!