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These include preventing insurance companies from denying coverage to people with pre-existing health conditions, banning limits on payouts for coverage, and allowing young people to stay on parents' insurance plans until the age of 26.
Despite this major victory, the president now faces the opposition party's intensified efforts to repeal the law. Republicans who control the House of Representatives scheduled a vote for July 11.
In the U.S. Senate, Republican minority leader Mitch McConnell spoke shortly after the court ruling was announced.
"Republicans will not let up whatsoever in our determination to repeal this terrible law and replace it with the kind of reforms that will truly address the problems it was meant to solve," he said.
Republican presidential candidate Mitt Romney said the court did not endorse the law as "good policy," and renewed his vow to repeal the legislation if he is elected.
"This is a time of choice for the American people. Our mission is clear. If we want to get rid of Obamacare we're going to have to replace President Obama. My mission is to make sure we do exactly that," he said.
After the court ruling, Republicans and opponents of the health care law renewed assertions that it will drive health care costs higher and add to the federal government's budget deficit and long-term debt.