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According to Health Ministry officials, the death toll would continue to rise. Earlier, the Health Ministry put the number at 40, while the opposition said around 100 people had been killed.
The White House National Security Council spokesman Mike Hammer said the United States is "closely" following the situation in Kyrgyzstan and felt concerned about reports of violence and looting, urging all parties to refrain from violence and exercise restraint.
UN Secretary-General Ban Ki-moon on Wednesday said he was "shocked" over the deadly clash in Kyrgyzstan and appealed for concerned parties to "show restraint."
"The secretary-general is shocked by the reported deaths and injuries that have occurred today in Kyrgyzstan," said a statement issued by Ban's spokesman.
"He once again calls on all concerned to show restraint," the statement said, "He urgently appeals for dialogue and calm to avoid further bloodshed."
The unrest on Wednesday came one day after Tuesday's violence in the northern Kyrgyz town of Talas, during which at least 15 police officers were missing, 16 civilians and 85 policemen were injured, Prime Minister Usenov said.