Suspected U.S. drones fired two missiles at a house in Mirali district in North Waziristan tribal agency bordering Afghanistan, said the report.
As a result, 20 people, mostly Arabs including an al-Qaida commander Abu Akash, were killed in the attack.
This is the latest of a string of cross-border missile attacks launched by U.S. drones in Pakistan's tribal regions.
As many as 11 people were killed and many others injured in a suspected U.S. missile attack in Miran Shah in North Waziristan one week earlier.
Pakistan's senators expressed their serious concern and condemnation about the cross-border attacks and asked the government to stop such attacks and protect Pakistan's sovereignty and territory integrity.